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Ligand binding to membrane proteins may be significantly influenced by the interaction of ligands with the membrane. In particular, the microscopic ligand concentration within the membrane surface solvation layer may exceed that in bulk solvent, resulting in overestimation of the intrinsic protein’ligand binding contribution to the apparent/measured affinity. Using published binding data for a set of small molecules with the 2 adrenergic receptor, we demonstrate that deconvolution of membrane and protein binding contributions allows for improved structure’activity relationship analysis and structure based drug design.

My friend then set up the third scenario. What if India and Pakistan were playing each other on the cricket field, whether in Britain or elsewhere? His son assumed, as would most people if similarly placed, that he ought to support Pakistan, but his father explained that the matter is more complex. Though Pakistanis lay claim to their own nation state, civilizationally speaking they are Indians as much as those who live in India.

Our wholesale online sunglasses business is perfectly placed to assist you in setting up your wholesale replica sunglasses business. We can provide very high quality sunglasses and sunglasses displays at very low prices. Being an online business means we can serve you no matter where you start your business.

This particular watch is great for sports like jogging, hunting, hiking, fishing, etc. The watch has many functions (compass, altimeter, thermometer, calendar, timers, and alarms) and the majority of them operate really well. The compass is trustworthy for finding the right way and the barometer forecasts weather changes.

Not everybody has skill in all areas. Not everybody is perfect in a field. If some one can not handle, it means wrong person at the wrong place (at wrong time).. The executive convinced me to book it for the sunrise which meant that we had to get up at 3 AM and be ready by 4AM. When we reached the spot, it was clear the driver had slept and forgotten and made a story that there is a strike. It wasted our entire day.

MC: Intermezzo is not a linear composition, but rather an associative network, a rhizomatic composing and performing that opens up several directions, an infinite web of possible routes. I could call it unstable music. Where stable music is aimed at laying down, certainty, and permanence (for example, in musical notation), unstable music is transient, fleeting, intangible, and playful.12 The result is impossible to predict.

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There nothing wrong with that. But there is a fine line between editing and altering, and it seems like more people are crossing it. To be clear: We give the influencers who posted photos we included in this article props for showing both the before versions of their photos edited with Lightroom Presets.

Background: Guidelines recommend extended thromboprophylaxis following colectomy for malignant disease, but not for non malignant disease. The aim of this study was to determine absolute and relative rates of venous thromboembolism (VTE) following colectomy by indication, admission type and time after surgery.Methods: A cohort study of patients undergoing colectomy in England was undertaken using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data (2001 “2011). Crude rates and adjusted hazard ratios (HRs) were calculated for the risk of first VTE following colectomy using Cox regression analysis.

I have owned property in co op buildings, condo buildings and single family homes. A lot of the complaints I have read on this thread certainly apply to a co op structure where you don’t own any real property, you technically own shares of a corporate structure which entitle you to the unit you purchased. The co op board can make your life difficult, particularly if you are looking to rent.

Intrigu, Andrew Niccol a approfondi ses recherches. Il en est sorti dstabilis. Fut un temps o les soldats partaient au front, combattaient, puis, au bout de quelques mois, rentraient au pays. Merci Zinedine, t’as tout bon. Mais le plus curieux dans cette histoire de manifestation, c’est que j’ai eu beau demander tous les acteurs du drame, du simple porteur de drapeau au barbu le plus farouche, en passant par le policeman au coin de la rue, bonne distance, personne n’a su m’informer sur les tenants et les aboutissants de l’vnement. On en restera l, quoi que je serais curieux de savoir ce que vont en rapporter nos amis les mdias..

For food or for fuel, but also to the impacts of consumption on marginalised people, particularly in the global South. While the debate has provided a useful hook on which to hang criticisms of increased demand for biofuels, it also masks a more complex reality. In particular, the multifaceted and global linkages between the stewardship of land, the food sector, and global energy policies.

The official dress code was ‘semi professional’, and the more I researched it on the web, the more I found that there was so much more out there than going for a block stripe tie, for example. I’m more smartly dressed than the average digital marketer; our CEO would wear jeans and a hoodie if he didn’t have to go to a client meeting. I think I’m the only one out of 400 500 people who wears a jacket and tie on a daily basis.

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We generated a synthetic glycoprotein (GP) construct based on the earliest reported isolate and introduced amino acid substitutions that defined viral lineages. Mutant GPs were used to generate a panel of pseudoviruses, which were used to infect different human and bat cell lines. These data revealed that specific amino acid substitutions in the EBOV GP have increased tropism for human cells, while reducing tropism for bat cells.

En chaussant les fameuses Wayfarer dans Risky Business, o il est tte d’affiche, l’acteur va doper les ventes de Ray Ban et surtout remettre la mode le modle mythique de la marque lanc en 1952, avec 360 000 paires vendues en 1983 contre 18 000 auparavant. Il ritre l’exploit trois ans plus tard dans Top Gun o, cette fois, il porte les Aviator 3025. Les ventes de Ray Ban s’envolent et augmentent de 40 % en 1986 ! Le film, qui a propuls Tom Cruise au rang de star mondiale,..

Once installed, the 8,000 BTU in window Aros works similarly to an AC unit tied to a Nest or Honeywell Wi Fi Smart Thermostat. Once you complete the setup, you can control settings on the window unit using the free WINK smartphone app. As you adjust temperature higher or lower on sweltering summer days, Aros learns about you and your preferences in order to build an automatic schedule..

Yes, poooooooor Wall Street. Bloomberg also said he wants to ensure that “people who don’t want to protest can go down the streets unmolested” and cited “societal concerns,” such as sanitation. Such material is made available to advance understanding of ecological, Political, Human Rights, economic, scientific, Moral, Ethical, and Social Justice issues, etc.

When speaking of particular notes of a raga, Rahaim mostly uses the sargam abbreviations such as sa, re, ga, etc., but occasionally intersperses their full names such as saraj, risabh, and gandhar. This is not incorrect, just a little distracting. The Hindustani honorific “ji,” added to the names of respected people, is also used inconsistently.

Besides having geniuses in design, software and retail, Apple also has the cash to invent components, manufacturing processes and things like that, which almost makes it impossible for the competition to make any real headway against Apple. And don’t let the fact that Android has become the No. 1 smart phone operating system make you think that it the big winner.

The second suspect is white, very skinny with a bony, narrow chin. He is approximately 17 years old and was taller than five feet 10 inches with light brown hair. He was wearing a light grey baseball cap with a red clasp, and wore it backwards on his head.

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Our favorite was “Temperance,” showing Mrs. Pierce, ax in hand, leading a group of women using rope to tug a saloon off its foundation an event that took place in 1883. The women towed the saloon for a block, and the streets ran with whisky. Wealthy people see big picture. For instance, a wealthy person may see e fuel station as a cash register whilst a poor person may see it just as a fuel station. It’s not bad to dream big.

“We were inundated with a slew of qualified candidates,” said Kyle Campbell, HBA PAC Chairman. “We are pleased to endorse candidates with strong business backgrounds who believe in the process of city government, the principles of limited government, and allowing the private sector to work. All endorsed candidates demonstrate great leadership skills and the ability to build a consensus and will be an asset to our community as members of City Council.

What’s On(Image: Manchester Evening News)Get the biggest Manchester Family stories by emailSubscribe We will use your email address only for sending you newsletters. Please see ourPrivacy Noticefor details of your data protection rightsThank you for subscribingWe have more newslettersShow meSee our privacy noticeCould not subscribe, try again laterInvalid EmailIf you not yet been to Manchester Ice Village then organisers are giving families a festive treat.The Ice Cavern and Skate Manchester ice rink opened last month and once again form the centrepiece of the Christmas Markets family zone in Cathedral Gardens.This year there a Fantasy Adventure theme, featuring mythical beasts and royal regalia.What’s OnallMost ReadMost RecentShoppingRaheem Sterling’s H advert has Instagram talking for all the right reasonsThe Manchester City footballer has been inundated with comments about his latest Instagram postChristmasHow to get cheaper tickets to Manchester’s Ice Village with exclusive MEN discount codeThe exclusive MEN discount code can get you almost a third off family ticketsChristmasWinter Funland at EventCity 2019 ticket prices, times and all you need to knowThe festive extravaganza is back at EventCity with rides, an ice rink, circus and moreSpinningfieldsThe best bars in Spinningfields and Deansgate, from The Ivy to 20 StoriesThere are cocktails galore in this glamorous corner of ManchesterManchester restaurantsWhere Manchester’s restaurant and bar staff go to eat and drinkWhere do the city’s hospitality insiders spend their nights off? We asked some of themMost ReadMost RecentFredWhy Fred was Manchester United’s man of the matchFred was superb in his first Manchester derby appearance at the Etihad Stadium, where Man United beat Man City 2 1 to top a wonderful week.Player ratingsManchester United player ratings: Marcus Rashford and Fred brilliant vs Man CityMan Utd beat Man City in the Manchester derby thanks to goals from Marcus Rashford and Anthony Martial.Manchester United FCPep Guardiola reaction proves the Manchester United plan is starting to workMan Utd were 2 1 winners against Manchester City in the Manchester derby after an excellent performance.National LotteryNational Lottery Lotto results and draw LIVE: Winning numbers for Saturday December 7 Results checker for tonight’s UK Lotto and Thunderball draw results and winning numbers for today Saturday December 7Manchester derbyMan City issue statement after video appears to show supporter making racist gesture towards Man Utd playersManchester City say they are aware of images appearing to show a supporter making racial gestures in the defeat to Man United.Greater Manchester PolicePolice have confirmed they are investigating reports of alleged racist abuse during the Manchester derbyGreater Manchester Police confirmed in a statement they are ‘aware’ of the video circulating on social mediaFredFred reacts to alleged racist abuse after Manchester United beat Man CityFred appeared to be subject to racist abuse from a member of the crowd during Man United’s win at Manchester City.BBCStrictly fans rejoice as Kelvin Fletcher FINALLY gets perfect score and he was lost for wordsIt comes just a week after fans of Kelvin and dance partner Oti Mabuse hit out at judge Craig Revel Horwood for failing to give Kelvin Fletcher the score they think he deserves.I’m A Celebrity. Get Me Out Of HereI’m A Celebrity’s Kate Garraway in for a surprise when she leaves jungle thanks to Twitter accountThe Good Morning Britain presenter has been getting stuck in to the ITV reality series with plenty of Bushtucker Trials and challenges all ticked off the I’m A Celeb bucket list.Manchester United Transfer NewsManchester United news and transfers RECAP early team news as Pogba ruled out of Manchester derbyRecap all the latest Man Utd news and transfer gossip ahead of the Manchester derby and Ole Gunnar Solskjaer’s pre match press conference.Jesse LingardManchester United confirm Lingard and Fred reported racist abuse in Manchester derbyFred and Jesse Lingard were abused during the Manchester derby and the Man United pair told club officials it was racist abuse.Jesse LingardJesse Lingard reacts to alleged racist abuse in Manchester derbyMan Utd won the Manchester derby 2 1 at the Etihad Stadium after goals from Marcus Rashford and Anthony Martial.Gary NevilleGary Neville accuses Boris Johnson of fuelling racism after derby day incidentsBoth clubs are now working to identify the person in the video and City said they are “working with Greater Manchester Police in order to help them identify any individuals concerned”..

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Health minister has briefed all the assembly members and requested them to get involved personally so that we can finally defeat polio, he said. Shah said refusal will not be tolerated this time round. He urged each and every parent to cooperate with the polio workers and ensure proper vaccination to their children.

Kansas Jayhawks, please stand up! My boys in crimson and blue have been rocking this tournament. I told you guys not to count them out. Now, we’re in the Final Four and only two teams stand in between us and that trophy. With the 2 in 1 Orbi Tri band Wi Fi Cable Modem System replacing your existing cable modem and router, you will step up to an experience of ultra fast mesh Wi Fi coverage for your home. Compatible with all major cable internet service providers, the Orbi Tri band Wi Fi Cable Modem System is designed to work, right out of the box, with Xfinity from Comcast XFINITY, Spectrum, Coxand more. This new modem router will soon pay for itself with the money you save by eliminating equipment leasing fees from your internet provider..

Banks to Drug Cartels?Last month, the House of Representatives passed a bill known as the SAFE Banking Act, a seemingly innocuous bill offering the nascent, state legal marijuana industry access to banks. Interestingly, many House Republicans who claim to oppose marijuana legalization voted in support of the bill. Biden pledge came as a response to a question from an audience member at the MSNBC Public Education Forum.

We ended up anointing a humble sammie that drew very few reviews on Yelp. Other fried chicken sandwiches around town tower over SODO Chicken squat one by a good 1 to 2 inches, but don’t let appearances fool you. The ratio of juicy dark meat to craggy crust is perfect, and it is structurally impeccable, the batter sticking to the meat and never falling apart, like many other fried chickens.

The acceptance letters are rolling in, and your last days of high school are fast approaching. But despite your excitement, you might be feeling a little apprehensive. After all, all you know is high school. I tolerate other cats, and the dogs in my foster’s home, but I’d rather be an only cat. If a person has me, why would they need anyone else? If you’re looking for a big bundle of purrfection to hang out with, look no further. I’m the girl for you.Echo, domestic shorthairEcho is a male domestic shorthair cat being kept at Friends For Life Animal Shelter Sanctuary.He is already neutered, and he has all his shots.

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Armed Forces remain the most lethal and combat effective fighting force in the world, Lt. Col. Carla Gleason, a Pentagon spokesperson, told CNN.. Now, again, I fought off the depression episode and suicidal thoughts tonight, but it was worse now than before. A lot worse. She never acted like this.

The Top End is home to a third of Australia bird species and every year in September/October hosts Kakadu Bird Week. I struggling to imagine what that must be like after what I saw in May. We drove right by huge flocks of red tailed black cockatoos, the of Aboriginal mythology.

Hawkins was rebuffed by Jahangir, but Sir Thomas Roe, who presented himself before the Mughal Emperor in 1617, was rather more successful. Two years later, Roe gained Jahangir permission to build a British factory in Surat, and in 1639, this was followed by the founding of Fort St. George (Madras).

Meanwhile, certain antibiotics, such as ciprofloxacin (Cipro), can interfere with the breakdown of caffeine in your body, extending the amount of time it stays in your system and prolonging its effects, such as insomnia or a bad case of the jitters. The herbal supplement echinacea can also do this. But is still found in some congestion relievers).

She is so diligent and warm/welcoming. There are many choices but for me . There is only 1 THE SHORE CLUB !!!!Eugene Hanglow. Facebook has just spent $2bn on start up Oculus VR, in a bet that virtual reality headsets will be the next big social platform after smartphones. The world largest social network thinks virtual reality will become part of everyone daily life, being used in everything from entertainment to education. This is Facebook second big deal of the year, as Mr Zuckerberg goes on an acquisition spree to help maintain its dominance.

The vote by the court’s criminal chamber declared that individuals should have the right to grow and distribute marijuana for their personal use. While the ruling does not strike down current drug laws, it lays the groundwork for a wave of legal actions that could ultimately rewrite them, proponents of legalization say. Today, the flow of drugs to the United States continues, along with the political corruption it fuels in Mexico.

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These shades are an integral part of the highly sought after fashion statement by fashion lovers. While buying Ray Ban sunglasses, shoppers find it difficult to buy only one. Sunglasses are just convenience for many people. Kahkonen made 27 saves. The Wild won in its final game of the week with a 3 0 shutout victory against the Reign Sunday in Iowa (11/10). Mayhew, F Cody McLeod and Sturm netted a goal apiece.

You’ve ever experienced a situation where you’re on iOS and a friend next to you has an Android phone, sending something like a big batch of photos or a long video is a challenge, the filesharing company said in a blog post. Shoot app was developed to make this easy. If you have a Windows Phone 8.1 device, you can download nine of the company titles at no cost till June 17..

My biggest moment of truth was when I was introduced to Video News Releases (VNRs). (Paid) advertisements that attempt to mirror real broadcast news stories made me consider the deception throughout all news mediums. Associate marketing and sponsored stories online, product placement in magazines and product/restaurant reviews in newspapers made me realize that consumerism pervades our society so deeply, viable business models must adapt in order to stay afloat..

Shares in Luxottica soared nearly 5% today in Rome. CEO Andrea Guerra told the Italian newspaper La Repubblica that the push to market will be in 2015 and that the Google partnership should help guarantee the eyewear maker annual growth of 5 to 10%. Google Glass is a computing device that includes a thumbnail sized screen above the wearer’s right eye to view Internet content..

Report also shows trace amounts of methamphetamine in Irons system. His wife says she insists the surfing champ did not use methamphetamine, it is likely the substance was present in the cocaine he ingested. Irons said that looking back, she does remember a few instances in the last year in which her husband complained of chest pains or occasional heartburn.

9 Dem candidates demand DNC toss out current debate rulesNine Democratic presidential candidates, including the party front runners, are urging the Democratic National Committee to reopen televised debates to a broader pool of contenders to better reflect the historic diversity of the current field. But party officials signaled Saturday that they are unlikely to budge and change the rules used in recent months to determine who makes the stage. In the letter obtained by CBS News, the candidates say that the rules used in recent months to determine who will appear “have unnecessarily and artificially narrowed what started as the strongest and most diverse Democratic field in history before voters have had a chance to be heard.”Strong quake kills 1, collapses building in PhilippinesA strong earthquake jolted the southern Philippines on Sunday, killing at least one person and causing a three story building to collapse, setting off a search for people feared to have been trapped inside, officials said.

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Potter has some important things to say through his expansive survey. The link he provides between singing and English Received Pronunciation, which even extends to the performance of songs by American composers such as Aaron Copland, demonstrates the influence of class on the song Important also is his opinion that what he describes as an elite form of singing will eventually be reduced to a stylized art form with little relevance to modern society. This process can similarly be identified in other art forms, much in the way of the Noh Theatre of Japan.

And Giard, M. And Giraud Hraud, Y. And Gjerlw, E. A brother in law of Denaro, Vito Panicola, was convicted for unwillingly killing his son in an attempt to kill another man. Vito Panicola was a member of the governing council of Trapani. At this moment there are dozens of similar cases all across Italy.

This is necessary to enable the calculation of a national tariff. The conceptual flaws of the Health of the Nation Outcome Scale led to the constructional shortcomings which compromised the credibility and validity of Mental Health Clustering Tool regarding making accurate classification in a standardised way. The validity and credibility of calculating a national tariff thus became contentious on the basis of this inaccurate clinical classification system.” This paper explored the driving factors of delay in implementing PbR in mental health through connecting the recent reform with the fundamental assumptions of standardisation to the average , which provided another perspective to illustrate the current obstacles..

(Privacy Policy)AkismetThis is used to detect comment spam. (Privacy Policy)HubPages Google AnalyticsThis is used to provide data on traffic to our website, all personally identifyable data is anonymized. (Privacy Policy)HubPages Traffic PixelThis is used to collect data on traffic to articles and other pages on our site.

As far as time dependence is concerned, we allow for all idiosyncratic components (both in the common stochastic trend and in the error term) to follow a linear process, thus considering a highly flexible specification for the serial dependence structure of our data. (1992). Mortality.

Initially, the solution was wearing sun shades and then the sunglasses. However, using the general sunglasses is not the best option. In order to reduce the glare distortion one has to compromise on the overall effect of light. The turning of the calendar from one year to the next has zero influence on great companies. Long term investors should bypass this market timing discussion and stay long superb companies with positive trends. In my world, price is the ultimate arbiter of truth.

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If you aren’t seeing that please provide a couple of examples and we’ll investigate. WIP lenses should have been imported as unpublished hubs. Locked lenses are not imported. Paolo Sorrentino is Penn’s director, whom he plainly adores. (‘A special, special man, a gentle, poetic soul.’) They met at Cannes in 2008 when Penn, as the jury president, handed Sorrentino a prize for his Il Divo and confided that he would work with him ‘anytime, anywhere.’ A year later a script came in the post. ‘I read it and it rang sweet and true, so I called Paolo and said, “I’m in.” ‘.

Tunisians have been stocking up on water and milk after hearing rumors about the chaos the election would trigger. People linked with Ben Ali’s reign were suspected of having started the rumors. Members of Ben Ali’s party have been absorbed into some of the secular parties, and former ministers are leading two new parties, al Watan and al Mubadara..

We think that most likely there are genetic factors that play a role in susceptibility. And importantly, we need to figure out ways to treat individuals, rehabilitate them, so they don’t lead these tragic lives. If we could understand how this disease develops in its very early stages, we would have the best chance for treatment and a cure, so one of the critical groups to study is the individuals in their teens and twenties who have developed CTE..

For our experts, Hlne Capgras and Andr Mazal, this result is justified by the fact that “Ruinart is like the secret that everyone knows. A heart of range offer, an image well balanced between men and women’s values, a champagne both available in several point of sales but also rather discreet”. Last, we must remember that the Chardonnay grape is claimed by the house as the heart and soul of the Ruinart taste, both for its aromatic freshness and great delicacy.Two brands complete our top 3.

Von MaurMeet our Von Maur Store Managers! Follow along each week as a different Store Manager shares what’s new and what’s popular in their store. Stay up to date on your favorite Von Maur location! Our 29 Store managers are excited to share everything Von Maur with you!cannot leave the house without first using the new Spring Set Lanc Absolue Precious Cells. I begin my skincare regimen with Absolue Sublime Oleo Serum, then use the Absolue Precious Cells Day to replenish moisture, refine skin texture, color and reduce wrinkles.

This practice is known as Search Engine Optimisation (SEO). The main purpose of SEO is to build a website, which will be easily read by search engine algorithms. Using SEO practices is about generating more relevant web traffic for a website. We used four geodiversity variables (rock type richness, soil type richness, geomorphological diversity, hydrological diversity), in addition to four climatic and topographic variables, to account for threatened species diversity across 31 of Finland TMs national parks. We also analyzed rarity weighted richness (a measure of site complementarity) of threatened vascular plants, fungi, bryophytes, and all species combined. Our 1km2 resolution dataset included 271 threatened species from 16 major taxa.

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A bipartisan bill that offers a streamlined, long term visa for migrant agricultural workers and strengthens federal oversight of their employment passed the House of Representatives on Wednesday. Rep. Cathy McMorris Rodgers, and several of her Republican colleagues, on the same side of an issue as Democrats, even as Congress is gripped in a tight partisan battle over the potential impeachment of President Donald Trump..

That is the property of British Petroleum and we WILL sue you. Feed popularity is steadily climbing, with more than 38,000 followers as of Wedneday morning. By contrast, the actual BP America Twitter feed had about 5,600.. Faisal Devji’s The Impossible Indian is easily both one of the most stimulating and disturbing books in the Gandhian cornucopia. Devji proposes to set forth ‘a new case’ for Gandhi ‘to be considered one of the greatest political thinkers of our times’ (vii), just as the analytical philosopher Akeel Bilgrami, another relatively recent convert to Gandhi’s ideas, has argued that Gandhi was ‘the greatest anti imperialist theorist who ever wrote’. [See Akeel Bilgrami, ‘Gandhi’s religion and its relation to his politics’, in The Cambridge Companion to Gandhi, eds.

2.1 First notice that the distinction between having or not having causal effect is a property of nature, (or the data generating process), not of the model that you postulate. We can therefore ignore the diagram that Igor describes above. Now, in addition to quitting for lack of information, DAG based methods would tell you: you can give me some causal information, however qualitative, I will tell you if it is sufficient or not for answering your query.

It seems almost self evident that “knowledge management” and “knowledge engineering” should be related disciplines that may share techniques and methods between them. However, attempts by knowledge engineers to apply their techniques to knowledge management have been praised by some and derided by others, who claim that knowledge engineers have a fundamentally wrong concept of what “knowledge management” is. The critics point to specific weaknesses of knowledge engineering, notably that the captured knowledge often lacks any description of its context.

4. Rude staff I was snapped at by the pool attendant because I was using a Bali bed even though we made friends with someone that day who had left for a flight and they transferred it to us for the rest of the day. Why snap? Why not just ask us? 5.