Combining these, in the double mutant b2 H296K K305D, reduced salmeterol TMs affinity by 275 fold, to within 4 fold of that of the b1 adrenoceptor, without affecting the affinity or selectivity of other b2 agonists (salbutamol, formoterol, fenoterol, clenbuterol, or adrenaline). Another important amino acid was Y308 in transmembrane 7, although this also affected the affinity and selectivity of other agonists. F194 in extracellular loop 2 and R304 in extracellular loop 3 also had minor effects.
An analysis of commonly used document collections shows that test collections are not fully judged as achieving that is expensive and may be infeasible for large collections. A document collection being fully judged means that every document in the collection acts as a relevant document to a specific query or a group of queries. The discriminative approach used in our proposed approach is a heuristic method for improving the IR effectiveness and performance, and it has the advantage of not requiring previous knowledge about relevance judgements.
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