There were no statistically significant associations between maternal NRT and system specific anomalies except for respiratory anomalies (OR: 4.65 [99% CI: 1.76 “12.25]; absolute risk difference: 3 per 1000 births), which was based on 10 exposed cases.CONCLUSIONS: For most system specific MCAs, we found no statistically significant increased risks associated with maternal NRT prescribed during pregnancy, except for respiratory anomalies. Although this study is the largest published to date, NRT use in pregnancy remains rare; thus, the statistical power was limited. Higher morbidities in those women prescribed NRT may also be an explanatory factor.
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