The SpiroMeta CHARGE consortium undertook the largest genome wide association study (GWAS) so far (n=48 201) for forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FEV1/FVC) in the general population. The lung expression quantitative trait loci (eQTLs) study mapped the genetic architecture of gene expression in lung tissue from 1111 individuals. We used a systems genetics approach to identify single nucleotide polymorphisms (SNPs) associated with lung function that act as eQTLs and change the level of expression of their target genes in lung tissue; termed eSNPs..
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We study the propagation of low frequency shallow water waves on a one dimensional flow of varying depth. When taking into account dispersive effects, the linear propagation of long wavelength modes on uneven bottoms excites new solutions of the dispersion relation which possess a much shorter wavelength. The peculiarity is that one of these new solutions has a negative energy.