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The intended audience for the reporting guidelines is broad and includes epidemiologists, geneticists, statisticians, clinician scientists, and laboratory based investigators who undertake genetic risk prediction studies, as well as journal editors and reviewers who have to appraise the design, conduct, and analysis of such studies. In addition, it includes “users” of such studies who wish to understand the basic premise, design, and limitations of genetic prediction studies in order to interpret the results for their potential application in healthcare. These guidelines are also intended to ensure that essential data from future genetic risk prediction studies are presented in standardised form, which will facilitate information synthesis as part of systematic reviews and meta analyses..