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Copy number variation (CNV) has been acknowledged as an important contributor to variation in the human genome, and copy variable regions harbouring genes are interesting subjects of research for their potential phenotypic effects. However, despite the extensive and continuing discovery of CNVs, multiallelic loci remain technically challenging to measure and study. In this thesis, a PCR based measurement system for the tandemly repeated CNV that harbours the DEFA1A3 locus has been developed.

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In comparison, only 15% of students taking in person classes failed one course, Graham said.The staggering fail rate left administrators scrambling to support students without lowering grading standards. The school created a credit recovery program, allowing students to earn back credits they lost from failed classes in the fall.The high school also asked any students who failed at least one online class this fall to take their classes in person this semester.Since then, half of all students who failed remote classes last semester and switched to in person are currently passing their classes, Graham said.”Our early results are looking very positive the kids that struggled online that are now back in person are doing significantly better in their classes,” Graham said.Educators have struggled with whether to assess student performance with the same pre pandemic academic standards, or to give more leeway given the challenging circumstances.”We all were in unchartered waters,” Graham said. “I think we did everything we could to keep our standards where they were, but also maybe giving kids a little more grace with getting their assignments in.”Detroit Public Schools Community District drastically altered the way it will grade students this year, eliminating all D and F grades from report cards because of the number of students who performed poorly in online learning in the fall.About 20% of elementary and middle school students and 35% of high school students failed at least one class in the first quarter.