Once this happens, your body’s blood clotting response is triggered, and a clot forms around the ruptured plaque. For people with CAD, this blood clot can block blood flow to your heart, causing a heart attack, or break off and travel to your brain, causing a stroke. With PAD, a blood clot can form in an artery of the limbs, such as the leg, causing pain or a more serious event that requires amputation.
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