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The lack of good correlation between IVCM and corresponding light microscopy for the same tissue samples has lead to speculative interpretations of IVCM images in the literature.In this work we tried to fill that gap through performing IVCM to patients with various corneal and ocular surface disorders just few days prior to obtaining the tissue samples (corneal graft, excisional biopsy or alcohol delamination) for histopathological examination to make sure that IVCM images were truly representative to the tissue details that might change if more time was left to elapse between IVCM and tissue sampling.In ocular surface disease group (chapter three) we contrasted IVCM criteria in conjunctival epithelial overgrowth onto the cornea in limbal stem cell deficiency and Pterygium like disorders with those seen in Corneal/Conjunctival Intraepithelial neoplasia (CIN) to confirm reliable diagnostic criteria of CIN with IVCM.In corneal oedema (chapter four) IVCM viewing of (histologically confirmed) subepithelial fibroblasts without clinically visible corneal scarring has been reported for the first time in IVCM literature particularly in Fuchs endothelial dystrophy. Sub basal corneal nerve reduction as well as stromal keratocytes and endothelial changes were clearly illustrated with IVCM.In keratoconus cases (chapter five) morphological epithelial changes related to regenerative atypia have been studied for the first time and compared to those seen in CIN through light microscopy and IVCM in addition to other epithelial changes associated with keratoconus. Novel IVCM criteria for Bowman’s zone breaks have been described and compared carefully with histological sections.In corneal dystrophies (chapter six) IVCM criteria in Thiel Behnke’s corneal dystrophy (CDBII) as well as in macular, granular and lattice dystrophy correlated well with light microscopic findings with a novel IVCM pattern in one Macular dystrophy case.In Acanthamoeba keratitis (chapter seven) a new form of Acanthamoeba cysts has been described for the first time through IVCM.Moreover this study presented for the first time IVCM diagnostic criteria in corneal intraepithelial neoplasia, keratoconus, Acanthamoeba keratitis and some corneal dystrophies.